Upon his return to Leoch in 1743, Jamie takes a beating on her behalf, trying to save her from humiliation, which she mistakenly interprets as a sign of reciprocated love. Jamie then goes with his uncle Dougal to collect rents, and returns married to Claire Fraser, which outrages Laoghaire. She puts an ill-wish under Jamie and Claire's bed, and tries to get Claire killed, of which Jamie is ignorant for many years.
In late 1764, after Jamie returns to Lallybroch from prison and indentured servitude, his sister Jenny Murray arranges a marriage between him and Laoghaire. However, the marriage is a failure, and within a year Jamie leaves Laoghaire and moves to Edinburgh.
Jamie later recalls that he seemed to always say the wrong thing, and that Laoghaire seemed to fear him when he tried to be close to her. Years later, Laoghaire admits that she knew Jamie did not need her, wouldn't truly look at her, and that lack made her turn away from him.
Upon Claire's return in November 1766, Laoghaire is furious and shoots Jamie in the arm. After the dust settles, Ned Gowan settles matters between Laoghaire and Jamie, drawing up a contract stating that Jamie would continue to support Laoghaire and her daughters until Laoghaire should remarry, as well as provide a dowry for each of the girls. Their marriage is declared invalid and Jamie leaves Scotland with Claire a short time later.
Jamie and Claire return to Lallybroch in January 1778. While there, Jamie pays Laoghaire a visit and apologizes for marrying her when he was incapable of loving her. They start arguing and Laoghaire attacks him. Jamie ends up beating her servant Joey, who is also Laoghaire's lover.
In March 1778, Claire and Laoghaire make a deal—Claire will go to Philadelphia to perform a surgery on Laoghaire's grandson, and Laoghaire will marry Joey, thus giving up Jamie's alimony.